Peter David reinvents X-Factor - again! Jamie Madrox has become a private eye. But with so many of his duplicates out in the world, is an identity crisis imminent? X-Factor Investigations recruits Guido, Wolfsbane, Siryn, M and Rictor - plus Layla Miller, who knows stuff! Can the team help mutantkind navigate M-Day and deal with their unbalanced former ally Quicksilver? X-Factor butts heads with Singularity Investigations, X-Cell, the Isolationist and more. But what happens when two of Madrox's dupes want their own lives - and when Jamie and Layla are thrown into the future? With Mutant Town under siege, Skrulls running rampant, personal problems tearing the team apart and a major change for Siryn, can X-Factor survive? Collecting MADROX #1-5; X-FACTOR (2005) #1-20, #21-24 (A STORIES) and #25-39; X-FACTOR: THE QUICK AND THE DEAD; X-FACTOR SPECIAL: LAYLA MILLER; and SHE-HULK (2005) #31.